Hydroquinone can lose a hydrogen cation from both hydroxyl groups to form a diphenolate ion. 57, 295300 (2013), R. F. Pires, M. R. Franco Jr, Fluid Phase Equilib. For a shipping quote, check the box and the bottom and provide us your shipping information. I would like to add retinol and kojic acid to it as well. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. Additionally, the hydroquinone compositions frequently discolor over time and turn from a whitish color to a brown or even black. Mobility in soil No additional information available 12.5. Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Eng. and solubility in water. All Rights Reserved, View All Eastman Hydroquinone USP Articles. D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. 2023 Springer Nature Switzerland AG. 0000008435 00000 n All information collection is solely used to support ChemPoint customers service communications. COMMON BRAND NAME (S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B . 2017-02-16T10:10:56+01:00 In the environment, hydroquinone showed increased toxicity for aquatic organisms, being less harmful for bacteria and fungi. I've been presented with the problem of trying to dissolve Hydroquinone in a solvent other than water. 0000004433 00000 n Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. I made my own hydroquinone 4% and added it to my cream. [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Read our Privacy Notice. Airborne hydroquinone may be oxidized to quinone at ordinary . In the United States, the most commonly used treatment for hyperpigmentation is 1,4-benzenediol, which is known as hydroquinone. 0000002221 00000 n Hydroquinone is considered to be readily biodegrable and photodegradable. One embodiment of the invention is a composition which comprises hydroquinone (about 1% to about 12%, preferably about 2% to about 10%, more preferably about 2% to about 8%, more preferably with about 2% to about 4%, and most preferably about 3% to about 4%) and has a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. . The FDA had classified hydroquinone in 1982 as a safe product - generally recognized as safe and effective (GRASE), however additional studies under the National Toxicology Program (NTP) were suggested in order to determine whether there is a risk to humans from the use of hydroquinone. If youd like my help or recipes for this bleaching cream please contact me on Instagram @kaylinell and @kay.linell or Facebook at kay linell. endstream endobj 276 0 obj <>stream Do not put this product in the microwave. InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, Except where otherwise noted, data are given for materials in their. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. NR 1L~tyj|ZZ3]jFlszH#bd]="nVj =rBF-=Y?Pe 3(\[3;wR-+7Fn ~pSQ(Rpiw^zYr''t@\vobE]u'C}io0q;^k5C@|zZNNA>,XOrztV;qO*w:MC$OI\_$Io 'v [ However, the oil-soluble TBHQ is more hydrophobic with a distinctly increased log P value compared to HQ. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. The experimental solubility data was well-correlated with the data, calculated by . Hydroquinone Safety Data Sheet according to Federal Register / Vol. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. The obtained results show that the . So, does anybody know of another solvent I could use that has a higher . Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. With respect to organic solvents, the solubility varies from 57% in ethanol to less than 0.1% in benzene. Canon 0000085850 00000 n Retinoids are included in the invention from about 0.01 to about 5%, preferably from about 0.025% to about 2.0%, more preferably from about 0.05% to about 1%, and most preferably from about 0.025% to about 0.5%. Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. &"oq YcbX.=a*t R@ They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. An acceptable carrier also possesses suitable aesthetic and cosmetic qualities and may include emollients, conditioners and the like. 20grams ofhydroquinonein 20oz is liquid is 10%. 0000053439 00000 n isosorbide, Ascorbic acid, i.e. I'd like the consistency to be thin like a gel so that it absorbs quicker. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. Eng. Phase A: Dissolve L-Ascorbic Acid in distilled water via agitation and gentle heating (warm, never hot or you will denature the ascorbic acid). It has a white-solid appearance. Thermodyn. 0000003660 00000 n Privacy Policy. For more information, please see our While patients suffer from pigmentation disorders, they may also suffer from other skin disorders and signs of aging, including but not limited to rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. 1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. 0000002379 00000 n Toxicol. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and . Cationic salts of acidic ascorbyl esters, including inorganic salts, preferably magnesium ascorbyl phosphate, and amino acyl derivatives, preferably aminopropyl ascorbyl phosphate, are preferred in this invention. The solubility was increased by addition of ethanol, reached a maximum . Magnesium ascorbyl phosphate (also called magnesium ascorbityl phosphate or magnesium L-ascorbyl-2-phosphate) has a chemical formula of C. In another embodiment, sodium metabisulfite and magnesium ascorbyl phosphate are used in about 0.01% (preferably from about 0.05% to about 0.5%, most preferably at least about 0.1%,) and about 0.5% (preferably from about 0.25% to about 3%, more preferably from about 0.25% to about 1%, and most preferably at least about 0.5%) respectively in a composition with about 4% hydroquinone. It is soluble in water. and our New experimental data are provided for the solubility of resorcinol in water and salicylic acid, resorcinol, hydroquinone in 1-octanol. Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. 0 7 r @ &. G(DC:!c?5w [QDP, f\01j&8ea]Ke~z d _5H^j0M.|Y^bYb[Rm~-[ImSv. ;4kNNw?r yn^EOwCDyd>_?TU^vyss*|g9A1 avr 2o~molpb|CZTu(70 CKRu)(5O_^6|Qta', uG70]'vt|n3Xh[vMTc.{o0Y#(O5\/mGfI+L0~1E1~hi:ZY_W6n*EaSn*R+I)Pw|y\^/te;yO. The toxicology of hydroquinone - relevance to occupational and environmental exposure. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. HlRMo0WB:NnVCnE4(i0 (1* )@NzHR!>i;8XaXnsO0LNT0l$B%"NAb0I9V *6/-\vn0W"fKF:AAgl:psRZ?k`&eB IUQ0ET;W#vL=@XwRG{-LHlTz]^s%OB(GF 11'I [27] Several such agents are already available or under research,[28] including azelaic acid,[29] kojic acid, retinoids, cysteamine,[30] topical steroids, glycolic acid, and other substances. Part of Springer Nature. At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. Thank you for your inquiry and interest in ChemPoint. AzA inhibits tyrosinase. Table I shows that at 5C, 4% hydroquinone compositions maintain their white color with the addition of at least about 0.01% sodium metabisulfite at the low pH ranges (from about 3.50 to about 5.50) and at least 0.05% sodium metabisulfite for pH about 6.0 to about 7.0. You take the cream, put it in a container, take the powder measurement and add it. Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. On this Wikipedia the language links are at the top of the page across from the article title. Your document download will begin shortly. Learn more about Institutional subscriptions, C. M. S. de Mendona, I. P. de Barros Lima, C. F. S. Arago, A. P. B. Gomes, J. Therm. Acta 423, 137144 (2000), S.-T. Lin, S. I. Sandler, Ind. If you have any specific questions, please include them in the comments section. 38, 565571 (2006), K. Carlsson, B. Karlberg, Anal. Eng. 2017-02-16T10:10:56+01:00 If you are already a ChemPoint customer then sign up for access to our online ordering website. It is a reducmg agent that is reversibly oxidized to semiquinone and quinone. Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. [17], An important reaction is the conversion of hydroquinone to the mono- and diamine derivatives. Hydroquinone, like phenols are very weak acids and can be deprotonated. A2, Designated state(s): Bioaccumulative potential Hydroquinone (123 -31 -9) Bioaccumulative potential Not established. This complex dissolves in hot water, where the two molecules dissociate in solution. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. Some documentation and label information may refer to the legacy brand. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection.Call a POISON CENTER or doctor/physician if you feel unwell.IF ON SKIN: Gently wash with plenty of soap and water.IF IN EYES: Rinse cautiously with water for several minutes. Some products also contain sunscreens. Thus, while cationic salts of acidic ascorbyl esters, preferably magnesium ascorbyl phosphate and aminopropyl ascorbyl phosphate, have beneficial antioxidant effects on the skin, the combination with hydroquinone in the invention results in a compatible and stable composition. endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream The drug is freely soluble in water and in alcohol. Compositions according to this invention may include dermatologically acceptable carriers. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. 338, 217223 (2013), S. H. Ali, F. S. Al-Mutairi, M. A. Fahim, Fluid Phase Equilib. Hydroquinone is combustible when preheated. Therefore, the solubility values of hydroquinone in different solvents are required; however, the data availability in the literature is poor.3-7 In this work, the solubility data of hydroquinone in water, methanol, ethanol, 2-propanol, ethyl acetate, butyl acetate, and acetic acid from 276.65 K to 345.10 K under atmospheric pressure were . Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. M1 and M2 microemulsions contain ethanol as co-surfactant. 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. Eng. I can only tell you how to mix the powder solution to the liquid solvent. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. Additionally, a water-soluble antioxidant, preferably a sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, may be helpful in stabilizing the hydroquinone composition. Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. One of these, 4-butylresorcinol, has been proven to be more effective at treating melanin-related skin disorders by a wide margin, as well as safe enough to be made available over the counter. Conversion factors (at 25C and normal atmospheric pressure) 1 ppm = 4.5 mg/m 3 1 mg/m 3 = 0.222 ppm Table 1. 2y.-;!KZ ^i"L0- @8(r;q7Ly&Qq4j|9 It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. ChemPoint will not under any circumstances release personal user information to individuals or companies. The protective system can be an entrapment system, a single or multi- laminar system, such as by the formation of vesicles such as a liposome or by utilizing wax, paraffin, silicone, polyethylene, or any material or system which protects the retinoid from oxidation. Find answers in our support articles. Hydroquinone (C 6 H 4 (OH) 2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. The present invention combats this problem, with hydroquinone compositions in the neutral pH range, preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. 77, No. The protective system can be an entrapment system, a single or multi-laminar system, such as by formation of vesicle, such as a liposome, or by utilizing wax, paraffin, silicone, polyethylene or any material or system which protects the retinoid from oxidation. Add the hydroquinone to the water. The disodium diphenolate salt of hydroquinone is used as an alternating comonomer unit in the production of the polymer PEEK. Formula of hydroquinone is . uuid:a150f3fd-7f22-4439-aa26-6f445f4017e5 A3, Free format text: How to dissolve Hydroquinone to make 4 oz. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. 250, 165172 (2006), F. L. Mota, A. J. Queimada, A. E. Andreatta, S. P. Pinho, E. A. Macedo, Fluid Phase Equilib. PubMedGoogle Scholar. Anal. While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. The Beaver: Its Life and Impact. You can expect to hear from a technical specialist within 1 business hour. :hS-g"s2Sj Ij=x'V]gPV8tt~qkAVXi|u}5;#.pl-/4JFQ.EP3&F.qa2hI{N qBmG(z#n [GN.}aazN(~8kux9#tnYwIHFuxW v9UNj&ffNW_\\Tc""8=_"7wC>svwQy\^4gF H][QzmlOI(B@ U4[Xb0,|m0*D"/#$\u(QI)RYg\;8 Yjh Chim. These phases (described below) are combined in a mixing tank with an in-line homogenizer as follows. Rev. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. Polysorbate 20 0.5% 0.15g. Appearance: Free-flowing white crystalsOdor: OdorlessMolecular weight: 110.11Empirical formula: C6H6O2Assay (Anhydrous basis): 99.0-100.5 %Melting point: 172-174CWater: 0.5 wt % max.Residue on ignition: 0.5 % maxSolubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol, Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMOExtremely low vapor pressureUSP GradeEuropean Pharma GradeDrug master file available upon request. Stir until uniform. Most preferably, when both a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, are present, the color of the hydroquinone composition is stabilized in the neutral pH range, preferably for greater than about six months, more preferably for greater than about twelve months and most preferably for greater than about eighteen months. ADS Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. Gravimetric method is used to measured hydroquinone solubility in water, ethanol and in water+ethanol binary mixtures at temperatures (293.15, 295.15, 298.15, 300.15, 303.15, 305.15, 308.15, 310.15 and 313.15)K. Mole fractions solubility of hydroquinone are correlated with temperature by using the Apelblat equation. The document was not able to download due to an unknown error. The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. 2008-2023 ChemPoint. 108. However, a problem with a formulation containing both retinoids and hydroquinone has been their incompatible pH ranges. Cookie Notice Eng. Reddit and its partners use cookies and similar technologies to provide you with a better experience. We will respond to you shortly. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent.
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